Water → 2-Chloro-6-methoxypyrazine

Participants

Reaction Steps

After dissolving 7.99 g of 2,6-dichloropyrazine in 100 ml of tetrahydrofuran, 11.3 ml of a 28% sodium methoxide-methanol solution was added dropwise while stirring at room temperature, and stirring was continued overnight. Water was added to the reaction solution, and extraction was performed with n-hexane. The organic layer was washed with water and saturated brine and dried over anhydrous magnesium sulfate, and then the solvent was distilled off, under reduced pressure to obtain the title compound (6.96 g, 90% yield).

Provenance & Evidence