Methyl iodide → HCID 54519254, compound

Participants

Reaction Steps

277 mg (0.53 mmol) of 5-(3-phenyl-2-propene-1-yl) 3-(2-trimethylsilylethyl) 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate was dissolved in N,N-dimethylformamide. 40 mg (1.0 mmol) of sodium hydride (60%, oily) was added to the obtained solution. Then 0.05 ml (0.8 mmol) of methyl iodide was added to the resultant mixture, and they were stirred at room temperature for 2 hours. N,N-dimethylformamide was evaporated under reduced pressure. Water was added to the residue. After the extraction with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The residue was purified by the silica gel chromatography (hexane/ethyl acetate=3/1) to obtain the title compound.

Provenance & Evidence