Piperidine → HCID 69590310, compound

Participants

Reaction Steps

655 mg (3.0 mmol) of cinnamyl acetoacetate, 0.34 ml (3.0 mmol) of 3-chlorobenzaldehyde and 0.0297 ml of piperidine were heated under reflux in 3.0 ml of benzene overnight while water was removed. The reaction liquid was washed with water and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The obtained residue was heated to 70° C. together with 370 mg (3.0 mmol) of (2-cyanoethyl) propiolate and 232 mg (3.0 mmol) of ammonium acetate under stirring in 3 ml of acetic acid for two nights. Acetic acid was evaporated under reduced pressure, and the residue was purified by the silica gel chromatography (hexane/ethyl acetate=3/2) to obtain the title compound.

Provenance & Evidence