3-Pentanamine → HCID 22249494, compound

HRID 890203Notes

Reaction equation

HRID 890203 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([I:12])=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:13])[C:3]=1[CH2:14][CH2:15]Cl.[NH2:17][CH:18]([CH2:21][CH3:22])[CH2:19][CH3:20]>>[CH2:19]([CH:18]([N:17]1[C:2]2[C:11]3[CH:10]=[CH:9][C:8]([I:12])=[CH:7][C:6]=3[N:5]=[C:4]([C:13]3[C:3]([CH3:4])=[CH:2][C:11]([CH3:6])=[CH:10][C:9]=3[CH3:8])[C:3]=2[CH2:14][CH2:15]1)[CH2:21][CH3:22])[CH3:20]

Participants

3

Reactant 2

HCID 120193-PentanamineHCID 22249769HCID 22249769, compound

Product 1

HCID 22249494HCID 22249494, compound

Procedure

A solution of 4-chloro-3-(2-chloroethyl)-7-iodo-2-methylquinoline (300 mg, 0.82 mmol) in 3-aminopentane (10.0 mL) was stirred at 200° C. for eight hours in a sealed tube. The mixture was evaporated, and the residue was purified by silica gel column chromatography (10-70% ethyl acetate/hexane), to give the title compound (39 mg) as a pale yellow oil.

Workup

  1. customThe mixture was evaporated
  2. customthe residue was purified by silica gel column chromatography (10-70% ethyl acetate/hexane)

Sources & evidence

ORD record
ord-76ff535cc1784eff8a7f3f7a7ef2e0d8
Source dataset
uspto-grants-2006_02
Patent number
US06995163B2

Reaction notes

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