反应详情

3-Aminopentane (5 mL) was added to a solution of ethyl 7-chloro-3-mesityl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-carboxylate (1.94 g, 5.22 mmol) in acetonitrile (20 mL), followed by heating under reflux for eight hours. The mixture was extracted with ethyl acetate, and the organic layer was washed with brine, dried over anhydrous magnesium sulfate and evaporated. The residue was purified by silica gel column chromatography (20% ethyl acetate/hexane), to give the title compound (1.70 g).

1. temperatureby heating
2. temperatureunder reflux for eight hours
3. extractionThe mixture was extracted with ethyl acetate
4. washthe organic layer was washed with brine
5. dry with materialdried over anhydrous magnesium sulfate
6. customevaporated
7. customThe residue was purified by silica gel column chromatography (20% ethyl acetate/hexane)