Water → HCID 22249963, compound

HRID 890218Notes

Reaction equation

HRID 890218 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([CH3:20])[C:10]([C:11]3[C:16]([CH3:17])=[CH:15][C:14]([CH3:18])=[CH:13][C:12]=3[CH3:19])=[C:6]2[N:5]=[C:4]([CH3:21])[C:3]=1[CH2:22][CH2:23]Cl.NC(N)=[S:27].C(=O)([O-])[O-].[Na+].[Na+].O>C(O)C>[C:16]1([CH3:17])[CH:15]=[C:14]([CH3:18])[CH:13]=[C:12]([CH3:19])[C:11]=1[C:10]1[C:9]([CH3:20])=[N:8][N:7]2[C:2]3[S:27][CH2:23][CH2:22][C:3]=3[C:4]([CH3:21])=[N:5][C:6]=12

Participants

6

Reactant 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 2723790ThioureaHCID 22249724HCID 22249724, compound

Product 1

HCID 22249963HCID 22249963, compoundYield 97.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 7-chloro-6-(2-chloroethyl)-3-mesityl-2,5-dimethylpyrazolo[1,5-a]pyrimidine (500 mg, 1.38 mmol), thiourea (105 mg, 1.38 mmol) and sodium carbonate (180 mg, 1.73 mmol) in ethanol (10 mL) was heated under reflux for one hour. After overnight, water was added and the resulting crystals were collected by filtration. The crystals were washed with water, to give the title compound (436 mg) as white crystals.

Workup

  1. temperatureunder reflux for one hour
  2. filtrationthe resulting crystals were collected by filtration
  3. washThe crystals were washed with water

Sources & evidence

ORD record
ord-442a3a528e784bb6b81627cb0bc5325b
Source dataset
uspto-grants-2006_02
Patent number
US06995163B2

Reaction notes

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