2,3-Dichlorobenzoyl chloride → (7-Ethyl-2-methyl-1H-indol-3-yl)(2,3-dichlorophenyl)methanone

Participants

Reaction Steps

14.2 ml of 3M of MeMgI in Et2O are placed under argon and 6.78 g of 7-ethyl-2-methyl-1H-indole in 40 ml of Et2O are added dropwise. After 30 minutes, 17.84 g of 2,3-dichlorobenzoyl chloride in 60 ml of Et2O are added dropwise and the reaction medium is left stirring for 2 hours. The reaction medium is run quickly onto a saturated NH4Cl solution. The extraction is carried out with Et2O (twice) and then the organic phase is washed with a 10% NaOH solution, water and then a saturated NaCl solution. 5.5 g of the expected compound are obtained.

Provenance & Evidence