Acetic Acid → HCID 22250468, compound

HRID 890265Notes

Reaction equation

HRID 890265 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:12]([S:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[CH:11]([CH2:23][C:24]([NH:26][OH:27])=[NH:25])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[C:28](O)(=O)[CH3:29]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:12]([S:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)(=[O:14])=[O:15])[CH:11]([CH2:23][C:24]3[N:25]=[C:28]([CH3:29])[O:27][N:26]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 178427376HCID 178427376, compound

Product 1

HCID 22250468HCID 22250468, compound

Procedure

The title compound, pale yellow oil, MS: m/e=416.3 (M+H+) was prepared in accordance with the general method of example 13 from (2RS,5SR)-2-[5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-N-hydroxy-acetamidine and acetic acid.

Sources & evidence

ORD record
ord-b252bd56f3d249c8a337c7e8a36036da
Source dataset
uspto-grants-2006_02
Patent number
US06995182B2

Reaction notes

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