HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → HCID 10292985, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | (2RS,5SR)-3-[5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionic acid methyl ester | HCID 69596717 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 10292985 | HCID 10292985 | — |
Reaction Steps
Reduction of (2RS,5SR)-3-[5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionic acid methyl ester with lithium aluminum hydride (1.5 eq.) in THF at RT, aqueous work-up and crystallization from EE/hexane yielded the title compound, white solid, m.p. 93° C. and MS: m/e=378.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06995182B2 |
| Source dataset | uspto-grants-2006_02 |
| ORD ID | ord-2db9239b0f9544aebda5c9d16cff44dd |
| Source note | uspto-grants-2006_02 |