HCID 69596791, compound → HCID 69596782, compound

HRID 890275Notes

Reaction equation

HRID 890275 reaction equation
C[O:2][C:3](=O)[CH2:4][CH2:5][C@H:6]1[CH2:10][CH2:9][C@@H:8]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[N:7]1[S:18]([C:21]1[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=1)(=[O:20])=[O:19]>C(Cl)(Cl)Cl>[F:17][C:14]1[CH:13]=[CH:12][C:11]([C@@H:8]2[N:7]([S:18]([C:21]3[CH:22]=[CH:23][C:24]([CH3:27])=[CH:25][CH:26]=3)(=[O:20])=[O:19])[C@@H:6]([CH2:5][CH2:4][CH2:3][OH:2])[CH2:10][CH2:9]2)=[CH:16][CH:15]=1

Participants

3

Reactant 1

HCID 69596791HCID 69596791, compound

Product 1

HCID 69596782HCID 69596782, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

white solid, m.p. 96° C., [α]D20=+97.5° (c=1.1287 in chloroform) and MS: m/e=378.2 (M+H+); [(2R,5S)-3-[5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionic acid methyl ester: colorless oil, [α]D20=+94.0° (c=1.0868 in chloroform) and MS: m/e=406.1 (M+H+)].

Sources & evidence

ORD record
ord-6ae0d8e143704cdda3a2410199ab7ca9
Source dataset
uspto-grants-2006_02
Patent number
US06995182B2

Reaction notes

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