2-Methylimidazole → HCID 22250423, compound

HRID 890286Notes

Reaction equation

Cl[CH2:2][CH2:3][CH2:4][CH:5]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[N:6]1[S:17]([C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=1)(=[O:19])=[O:18].[CH3:27][C:28]1[NH:29][CH:30]=[CH:31][N:32]=1>>[F:16][C:13]1[CH:14]=[CH:15][C:10]([CH:7]2[N:6]([S:17]([C:20]3[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=3)(=[O:18])=[O:19])[CH:5]([CH2:4][CH2:3][CH2:2][N:29]3[CH:30]=[CH:31][N:32]=[C:28]3[CH3:27])[CH2:9][CH2:8]2)=[CH:11][CH:12]=1

Participants

Reactant 2

HCID 127492-Methylimidazole

HCID 22250442HCID 22250442, compound

Product 1

HCID 22250423HCID 22250423, compound

Procedure

The title compound, colorless oil, MS: m/e=442.2 (M+H+), was prepared in accordance with the general method of example 82b from (2RS,5RS)-2-(3-chloro-propyl)-5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidine and 2-methyl-1H-imidazole.

Sources & evidence

ORD record: ord-63c6e59ab053471a955e9f30f9e39c8d
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06995182B2

Reaction notes

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