(2RS,5RS)-2-(4-chloro-butyl)-5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidine → (2RS,5RS)-2-{4-[5-(4-Fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-butyl}-5-methyl-2H-tetrazole

Participants

Role	Name	HCID	Charge
Reactant	(2RS,5RS)-2-(4-chloro-butyl)-5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidine	HCID 22250478	—
Reactant	HCID 178434708	HCID 178434708	—
Product	(2RS,5RS)-2-{4-[5-(4-Fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-butyl}-5-methyl-2H-tetrazole	HCID 22250529	—

Reaction Steps

The title compound, pale yellow oil, MS: m/e=458.4 (M+H+), was prepared in accordance with the general method of example 82b from (2RS,5RS)-2-(4-chloro-butyl)-5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidine and 5-methyl-1H-tetrazole.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06995182B2
Source dataset	uspto-grants-2006_02
ORD ID	ord-f77573104e7346c7abd8ea0f1c57e318
Source note	uspto-grants-2006_02