Imidazole → HCID 69596842, compound

HRID 890319Notes

Reaction equation

HRID 890319 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][C@H:6]1[CH2:10][CH2:9][C@@H:8]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[N:7]1[S:18]([C:21]1[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=1)(=[O:20])=[O:19].[NH:28]1[CH:32]=[CH:31][N:30]=[CH:29]1>C(Cl)(Cl)Cl>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C@H:8]2[N:7]([S:18]([C:21]3[CH:22]=[CH:23][C:24]([CH3:27])=[CH:25][CH:26]=3)(=[O:19])=[O:20])[C@@H:6]([CH2:5][CH2:4][CH2:3][CH2:2][N:28]3[CH:32]=[CH:31][N:30]=[CH:29]3)[CH2:10][CH2:9]2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 69596806HCID 69596806, compound

Product 1

HCID 69596842HCID 69596842, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound, colorless oil, MS: m/e=442.3 (M+H+) and [α]D20=−64.3° (c=0.2673 in chloroform), was prepared in accordance with the general method of example 82b from (2S,5S)-2-(4-chloro-butyl)-5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidine and 1H-imidazole.

Sources & evidence

ORD record
ord-3428ee95995b49d28033789cec9f747a
Source dataset
uspto-grants-2006_02
Patent number
US06995182B2

Reaction notes

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