Chloroform → HCID 69596715, compound

HRID 890321Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[N:12]([S:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[C@@H:11]([CH2:23][CH2:24][C:25]([NH:27][NH2:28])=[O:26])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH:29](Cl)(Cl)Cl>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[N:12]([S:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)(=[O:14])=[O:15])[C@@H:11]([CH2:23][CH2:24][C:25]3[O:26][CH:29]=[N:28][N:27]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 6212Chloroform

HCID 69596726HCID 69596726, compound

Product 1

HCID 69596715HCID 69596715, compound

Procedure

The title compound, light yellow oil, MS: m/e=416.1 (M+H+) and [α]D20=−80.1° (c=0.2211 in chloroform), was prepared in accordance with the general method of example 127 from (2R,5S)-3-[5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionic acid hydrazide and triethyl orthoformiate.

Sources & evidence

ORD record: ord-b895709af486437096f9a527f241b2a4
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06995182B2

Reaction notes

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