HRID890429

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10796

Cesium carbonate

CCs2O3

结构：FC(F)(F)c1ccc(-c2ncc(CCl)c(C3CC3)n2)cc1

HCID21935960

未命名化合物

HCID57675474

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)Cn1ccc2cc(OCc3cnc(-c4ccc(C(F)(F)F)cc4)nc3C3CC3)ccc21

HCID69642003

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in example 1 h], 5-chloromethyl-4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidine was reacted with (5-hydroxy-indol-1-yl)-acetic acid ethyl ester (example 1 c]) in the presence of cesium carbonate to give {5-[4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester, which was subsequently treated with lithium hydroxide in analogy to the procedure described in example 1 i] to yield {5-[4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid.

WORKUP

后处理

customdescribed in example 1 h

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4a5f7624697045fba29eb493d67a60c5
来源数据集: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06995263B2
来源说明: uspto-grants-2006_02

反应 SMILES

Cl[CH2:2][C:3]1[C:4]([CH:19]2[CH2:21][CH2:20]2)=[N:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)=[N:7][CH:8]=1.[CH2:22]([O:24][C:25](=[O:37])[CH2:26][N:27]1[C:35]2[C:30](=[CH:31][C:32]([OH:36])=[CH:33][CH:34]=2)[CH:29]=[CH:28]1)[CH3:23].C(=O)([O-])[O-].[Cs+].[Cs+]>>[CH2:22]([O:24][C:25](=[O:37])[CH2:26][N:27]1[C:35]2[C:30](=[CH:31][C:32]([O:36][CH2:2][C:3]3[C:4]([CH:19]4[CH2:21][CH2:20]4)=[N:5][C:6]([C:9]4[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=4)=[N:7][CH:8]=3)=[CH:33][CH:34]=2)[CH:29]=[CH:28]1)[CH3:23]