Hydrochloric Acid → HCID 11419653, compound

Participants

Reaction Steps

70 mg (0.15 mmol) (5-{methyl-[4-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethyl]-amino}-indol-1-yl)-acetic acid methyl ester and 0.3 ml 1N lithium hydroxide solution were stirred for 2 h in 0.5 ml THF at RT. To the reaction mixture was added 0.6 ml 1N HCl and then the mixture was taken up in AcOEt and washed with water. The crude product was suspended in ether/heptane 1:19. The resulting crystals were filtered off to provide 47 mg of pure (5-{methyl-[4-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethyl]-amino}-indol-1-yl)-acetic acid.

Provenance & Evidence