Potassium Iodide → HCID 69642248, compound

Participants

Reaction Steps

A mixture of (6-hydroxy-indol-1-yl)-acetic acid ethyl ester (example 6 b]; 50 mg, 0.23 μmol), 5-chloromethyl-4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidine (example 3 d]; 78 mg, 0.25 μmol), cesium carbonate (82 mg, 0.25 μmol) and a trace of potassium iodide were suspended in acetone (5 ml). The suspension was stirred at ambient temperature for 72 h, the solvent was evaporated under reduced pressure and the residue dissolved in 1 N HCl/ice water 1/1 and ethyl acetate. The layers were separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed two times with brine/ice water 1/1 and dried over sodium sulfate. The solvent was removed under reduced pressure and the residue purified by column chromatography (silica gel, heptane/AcOEt) to give 71 mg (0.14 μmol, 63%) of the title compound as colorless crystals.

Provenance & Evidence