HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 69642331, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Di-tert-butyl azodicarboxylate | HCID 97268 | — |
| Reactant | 2-[2-Methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethanol | HCID 21935831 | — |
| Reactant | tert-Butyl (6-hydroxy-1H-indol-1-yl)acetate | HCID 69283069 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 69642331 | HCID 69642331 | — |
Reaction Steps
In analogy to the procedure described in example 5 f], (6-hydroxy-indol-1-yl)-acetic acid tert-butyl ester (example 5 b]) was reacted with 2-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethanol in the presence of di-tert-butyl azodicarboxylate and triphenylphosphine in tetrahydrofuran to yield (5-{2-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-indol-1-yl)-acetic acid tert-butyl ester as colorless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06995263B2 |
| Source dataset | uspto-grants-2006_02 |
| ORD ID | ord-7e33ddf099d84a98a118106e10d0f7fd |
| Source note | uspto-grants-2006_02 |