反应详情

6-(4-Trifluoromethoxy-phenyl)-pyridine-3-carbaldehyde (2.0 g, 7.48 mmol) was dissolved in EtOH (37 ml) and treated at 0° C. with NaBH4 (0.28 g, 7.48 mmol). After 10 min the cooling bath was removed and stirring was continued at ambient temperature. Pouring onto crashed ice, twofold extraction with AcOEt, washing with water, drying over sodium sulfate, and evaporation of the solvents afforded 2.08 g (7.7 mmol, quant.) of the title compound as off-white solid of mp. 57–58° C.

1. customAfter 10 min the cooling bath was removed
2. customwas continued at ambient temperature
3. additionPouring
4. extractionice, twofold extraction with AcOEt
5. washwashing with water
6. dry with materialdrying over sodium sulfate, and evaporation of the solvents