HRID890471

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4875

Potassium iodide

HCID10796

Cesium carbonate

CCs2O3

结构：COCCc1nc(-c2ccc(C(F)(F)F)cc2)nc(C)c1CCl

HCID21935749

未命名化合物

HCID68821422

(6-Hydroxy-indol-1-yl)-acetic acid ethyl ester

C12H13NO3

PRODUCTS

生成物

结构：CCOC(=O)Cn1ccc2ccc(OCc3c(C)nc(-c4ccc(C(F)(F)F)cc4)nc3CCOC)cc21

HCID69637739

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

In analogy to the procedure described in example 7 a], (6-hydroxy-indol-1-yl)-acetic acid ethyl ester (example 6 b]) was reacted with 5-chloromethyl-4-(2-methoxy-ethyl)-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine in the presence of cesium carbonate and potassium iodide, using acetonitrile as solvent, to obtain the title compound as colorless crystals.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-93e1569ebbc24625ad3176741c37fe16
来源数据集: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06995263B2
来源说明: uspto-grants-2006_02

反应 SMILES

[CH2:1]([O:3][C:4](=[O:16])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([OH:15])[CH:13]=2)[CH:8]=[CH:7]1)[CH3:2].Cl[CH2:18][C:19]1[C:20]([CH2:36][CH2:37][O:38][CH3:39])=[N:21][C:22]([C:26]2[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=2)=[N:23][C:24]=1[CH3:25].C(=O)([O-])[O-].[Cs+].[Cs+].[I-].[K+]>C(#N)C>[CH2:1]([O:3][C:4](=[O:16])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH2:18][C:19]3[C:20]([CH2:36][CH2:37][O:38][CH3:39])=[N:21][C:22]([C:26]4[CH:27]=[CH:28][C:29]([C:32]([F:35])([F:33])[F:34])=[CH:30][CH:31]=4)=[N:23][C:24]=3[CH3:25])[CH:13]=2)[CH:8]=[CH:7]1)[CH3:2]