反应详情

3-Amino-4-cyclopropyl-but-2-enoic acid ethyl ester (231 mg, 1.4 mmol) was added to a solution of (Z)-4,4,4-trifluoro-3-hydroxy-1-(4-trifluoromethoxy-phenyl)-but-2-en-1-one (819 mg, 2.7 mmol; example 16 a]) in acetonitrile (2.7 ml). The mixture was heated under reflux conditions for 12 h, the solvent was removed under reduced pressure and the residue purified by flash chromatography (silica gel, heptane/AcOEt) to give 242 mg (0.56 mmol, 41%) of the title compound as yellow oil.

1. temperatureThe mixture was heated under reflux conditions for 12 h
2. customthe solvent was removed under reduced pressure
3. customthe residue purified by flash chromatography (silica gel, heptane/AcOEt)