Sodium Cyanide → HCID 22250823, compound

HRID 890492Notes

Reaction equation

HRID 890492 reaction equation
Cl[CH2:2][C:3]1[C:4]([CH:19]2[CH2:21][CH2:20]2)=[N:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)=[N:7][CH:8]=1.[C-:22]#[N:23].[Na+]>>[CH:19]1([C:4]2[C:3]([CH2:2][C:22]#[N:23])=[CH:8][N:7]=[C:6]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:16])[F:18])=[CH:11][CH:10]=3)[N:5]=2)[CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 8929Sodium CyanideHCID 219359605-Chloromethyl-4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

Product 1

HCID 22250823HCID 22250823, compound

Procedure

In analogy to the procedure described in example 8 b], 5-chloromethyl-4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidine (example 3 d]) was reacted with sodium cyanide to give the title compound as white crystals.

Workup

  1. customexample 3 d

Sources & evidence

ORD record
ord-3395b61b2aab47438d0dc8e21843cb04
Source dataset
uspto-grants-2006_02
Patent number
US06995263B2

Reaction notes

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