HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N,N',N'-Tetramethylazodicarboxamide → HCID 86597788, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N,N',N'-Tetramethylazodicarboxamide | HCID 4278 | — |
| Reactant | Tributylphosphine | HCID 13831 | — |
| Reactant | HCID 21935734 | HCID 21935734 | — |
| Reactant | (6-Hydroxy-indol-1-yl)-acetic acid ethyl ester | HCID 68821422 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86597788 | HCID 86597788 | — |
Reaction Steps
In analogy to the procedure described in example 5 f], (6-hydroxy-indol-1-yl)-acetic acid ethyl ester (example 6 b]) was reacted with [6-(4-trifluoromethoxy-phenyl)-2-trifluoromethyl-pyridin-3-yl]-methanol in the presence of tributylphosphine and N,N,N′,N′-tetramethyl azodicarboxamide in tetrahydrofuran to yield the title compound as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06995263B2 |
| Source dataset | uspto-grants-2006_02 |
| ORD ID | ord-6b88c4cb940f404cbd78d5a94def90be |
| Source note | uspto-grants-2006_02 |