3-Amino-3-cyclopropyl-acrylic acid ethyl ester → 2-Cyclopropyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-nicotinic acid ethyl ester

Participants

Reaction Steps

In analogy to the procedure described in example 18 d], 3-amino-3-cyclopropyl-acrylic acid ethyl ester (J. P. Célérier, E. Deloisy, P. Kapron, G. Lhommet, P. Maitte, Synthesis 1981, 130–133) was reacted with (Z)-4,4,4-trifluoro-3-hydroxy-1-(4-trifluoromethoxy-phenyl)-but-2-en-1-one (example 16 a]) to give the title compound as colorless oil.

Provenance & Evidence