Aluminium lithium hydride → [2-Cyclopropyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-yl]-methanol

HRID 890501Notes

Reaction equation

HRID 890501 reaction equation
C([O:3][C:4](=O)[C:5]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][C:8]([C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=2)=[N:7][C:6]=1[CH:26]1[CH2:28][CH2:27]1)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH:26]1([C:6]2[C:5]([CH2:4][OH:3])=[C:10]([C:11]([F:12])([F:14])[F:13])[CH:9]=[C:8]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:23])[F:24])=[CH:17][CH:16]=3)[N:7]=2)[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 865977892-Cyclopropyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-nicotinic acid ethyl ester

Product 1

HCID 21935660[2-Cyclopropyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-yl]-methanol

Procedure

In analogy to the procedure described in example 16 c], 2-cyclopropyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-nicotinic acid ethyl ester was treated with lithium aluminium hydride to give the title compound as colorless crystals.

Sources & evidence

ORD record
ord-71cc7529cf5d4da0b89485000fc2475e
Source dataset
uspto-grants-2006_02
Patent number
US06995263B2

Reaction notes

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