(4-Nitrophenyl)acetic acid → HCID 2726119, compound

Participants

Reaction Steps

A mixture of p-anisidine (4.92 g, 40 mmol), 4-nitrophenylacetic acid (7.25 g, 40 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) (11.5 g, 60 mmol) in pyridine (40 mL) was stirred at room temperature overnight. The solvent was evaporated, and HCl (1M, 50 mL) was added. The resulting product was filtered and washed with water and ether, and recrystallized from ethanol to give N-(4-Methoxyphenyl)-2-(4-nitro-phenyl)-acetamide (9.6 g, 84%).

Provenance & Evidence