Hydrazine hydrate (1:1) → N-(1-(3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)ethyl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	Hydrazine hydrate (1:1)	HCID 24654	—
Reactant	Ethyl 3-acetamido-2-oxobutanoate	HCID 22245807	—
Reactant	2-(3,4-Dimethoxyphenyl)ethanimidamide hydrochloride	HCID 22245813	—
Product	N-(1-(3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)ethyl)acetamide	HCID 135697918	—

Reaction Steps

Analogously to Example 7A, 20.0 g (86.7 mmol) of 2-(3,4-dimethoxyphenyl)ethanamidine hydrochloride (Example 5A) are reacted with 5.21 g (104 mmol) of hydrazine hydrate and 24.3 g (130 mmol) of ethyl 3-(acetylamino)-2-oxobutanoate (Example 6A) to give N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}acetamide.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06998402B2
Source dataset	uspto-grants-2006_02
ORD ID	ord-4ee6ace81bc449eb9b4a983a9986615a
Source note	uspto-grants-2006_02