反应详情

温度

0 °C

3.08 g (17.9 mmol) of methyl 2-acetylhexanoate (Example 14A) is dissolved in 10 ml of dioxane and cooled to 0° C. 7.00 ml of a 3.5 M potassium hydroxide solution are added with cooling. After a reaction time of 5 h, the batch is concentrated, treated with 20 ml of ethyl acetate and 20 ml of water and extracted with shaking. The water phase is recovered, cooled to 0° C. and slowly treated with 1 N hydrochloric acid until a pH of 1 is reached. The mixture is then extracted with dichloromethane. The dichloromethane phase is dried and directly reacted further without concentrating.

1. temperaturewith cooling
2. concentrationAfter a reaction time of 5 h, the batch is concentrated
3. additiontreated with 20 ml of ethyl acetate and 20 ml of water
4. extractionextracted
5. customThe water phase is recovered
6. temperaturecooled to 0° C.
7. additionslowly treated with 1 N hydrochloric acid until a pH of 1
8. extractionThe mixture is then extracted with dichloromethane
9. dry with materialThe dichloromethane phase is dried
10. customdirectly reacted further
11. concentrationwithout concentrating