Sodium borohydride → 7-[1-(1-hydroxyethyl)hexyl]-5-methyl-2-(4-methylbenzyl)-imidazo[5,1-f][1,2,4]triazin-4(3H)-one
Reaction equation
[C:1]([CH:4]([C:10]1[N:18]2[C:13]([C:14](=[O:27])[NH:15][C:16]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=3)=[N:17]2)=[C:12]([CH3:28])[N:11]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])(=[O:3])[CH3:2].[BH4-].[Na+]>>[OH:3][CH:1]([CH:4]([C:10]1[N:18]2[C:13]([C:14](=[O:27])[NH:15][C:16]([CH2:19][C:20]3[CH:21]=[CH:22][C:23]([CH3:26])=[CH:24][CH:25]=3)=[N:17]2)=[C:12]([CH3:28])[N:11]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])[CH3:2]Participants
3
Procedure
100 mg (0.26 mmol) of 7-(1-acetylhexyl)-5-methyl-2-(4-methylbenzyl)-imidazo[5,1-f][1,2,4]triazin-4(3H)-one (Example 2) are reacted analogously to Example 8 with 15 mg (0.39 mmol) of sodium borohydride to give 7-[1-(1-hydroxyethyl)hexyl]-5-methyl-2-(4-methylbenzyl)-imidazo[5,1-f][1,2,4]triazin-4(3H)-one.
Sources & evidence
- ORD record
- ord-b8ab19c0963848099a06c676f6567b7b
- Source dataset
- uspto-grants-2006_02
- Patent number
- US06998402B2
Reaction notes
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