Sodium borohydride → 7-[1-(1-hydroxy-ethyl)heptyl]-5-methyl-2-(4-methylbenzyl)-imidazo[5,1-f][1,2,4]triazin-4(3H)-one
Reaction equation
[C:1]([CH:4]([C:11]1[N:19]2[C:14]([C:15](=[O:28])[NH:16][C:17]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=3)=[N:18]2)=[C:13]([CH3:29])[N:12]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])(=[O:3])[CH3:2].[BH4-].[Na+]>>[OH:3][CH:1]([CH:4]([C:11]1[N:19]2[C:14]([C:15](=[O:28])[NH:16][C:17]([CH2:20][C:21]3[CH:22]=[CH:23][C:24]([CH3:27])=[CH:25][CH:26]=3)=[N:18]2)=[C:13]([CH3:29])[N:12]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH3:2]Participants
3
Procedure
100 mg (0.25 mmol) of 7-(1-acetylheptyl)-5-methyl-2-(4-methylbenzyl)-imidazo[5,1-f][1,2,4]triazin-4(3H)-one (Example 3) are reacted analogously to Example 8 with 10 mg (0.25 mmol) of sodium borohydride to give 7-[1-(1-hydroxyethyl)heptyl]-5-methyl-2-(4-methylbenzyl)-imidazo[5,1-f][1,2,4]triazin-4(3H)-one.
Sources & evidence
- ORD record
- ord-424d49cbe7b34d28b6e3211458fe4f49
- Source dataset
- uspto-grants-2006_02
- Patent number
- US06998402B2
Reaction notes
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