Sodium borohydride → HCID 135532775, compound

HRID 890721Notes

Reaction equation

HRID 890721 reaction equation
[C:1]([CH:4]([C:11]1[N:19]2[C:14]([C:15](=[O:29])[NH:16][C:17]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)=[N:18]2)=[C:13]([CH3:30])[N:12]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])(=[O:3])[CH3:2].[BH4-].[Na+]>>[OH:3][CH:1]([CH:4]([C:11]1[N:19]2[C:14]([C:15](=[O:29])[NH:16][C:17]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)=[N:18]2)=[C:13]([CH3:30])[N:12]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH3:2]

Participants

3

Reactant 2

HCID 4311764Sodium borohydrideHCID 1354499567-(1-acetylheptyl)-2-(4-methoxybenzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

Product 1

HCID 135532775HCID 135532775, compound

Procedure

100 mg (0.24 mmol) of 7-(1-acetylheptyl)-2-(4-methoxybenzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (Example 5) are reacted analogously to Example 8 with 17 mg (0.45 mmol) of sodium borohydride to give 7-[1-(1-hydroxyethyl)heptyl]-2-(4-methoxybenzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one.

Sources & evidence

ORD record
ord-3fafd61c08a14e44acebc46bcb330506
Source dataset
uspto-grants-2006_02
Patent number
US06998402B2

Reaction notes

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