Hydrochloric Acid → HCID 9820676, compound

Participants

Reaction Steps

To a solution of the title compound of Step A (379 mg, 0.95 mmol) in MeOH (6 mL) was added NaOH (1.0 mL, 5N). The reaction was stirred at room temperature for 24 h and was acidified with aqueous HCl (1N). The MeOH was removed in vacuo and the residue was dissolved in CH2Cl2. The organic solution was washed sequentially with HCl (1N, 1×), water (2×), and brine (1×). The organic solution was dried with MgSO4, filtered, and concentrated in vacuo. Purification by radial chromatography (CH2Cl2 to 6% MeOH/CH2Cl2) provided the title compound (356 mg). 1H NMR (400 MHz, CDCl3) δ 7.30–7.12 (m, 4H), 4.35 (s, 2H), 3.10–3.19 (m, 2H), 2.80 (s, 3H), 2.60 (t, 2H), 2.31 (t, 2H), 1.48–1.65 (m, 7H), 1.20–1.40 (m, 6H). 0.97 (t, 3H); MS 387 (M+18).

Provenance & Evidence