HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 131725285, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Iodobenzoic acid | HCID 12085 | — |
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | Pentafluorophenol | HCID 13041 | — |
| Reactant | (3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol hydrochloride | HCID 2723635 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| Product | HCID 131725285 | HCID 131725285 | — |
Reaction Steps
To a solution of 4-iodobenzoic acid (1 mmol) in DMF (2 mL) was added pentafluorophenol (2 mmol) and diisopropylcarbodiimide (1.2 mmol). The solution was stirred at room temperature for 6 hours and then added to a solution of glucosamine hydrochloride (1 mmol) and NEt3 (2 mmol) in DMF/H2O (1 mL, 1:10 v/v). The reaction was stirred for 16 hours and then crystallized from hot water to yield 4-iodobenzoyl glucosamine, compound TP010. The structure of TP010 is shown below (R is I).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07001888B2 |
| Source dataset | uspto-grants-2006_02 |
| ORD ID | ord-f4523c1ac91d48d39ecce5bc0be97046 |
| Source note | uspto-grants-2006_02 |