HCID 69623856, compound → HCID 69623693, compound

Participants

Reaction Steps

To N-(propylsulfonyl)-D-isoleucyl-3-[(t-butoxycarbonyl)(methyl)amino]-N1-(4-cyanobenzyl)-L-alaninamide (1.6 g, 3 mmol), trifluoroacetic acid (10 ml) was added and stirred at room temperature under a nitrogen stream. After 1 hour, the reaction mixture was concentrated under reduced pressure and the residue was applied to column chromatography (Fuji Silysia NH-DM-1020; mobile phase: dichloromethane:methanol=1:0, 4:1) to give N-(propylsulfonyl)-D-isoleucyl-3-(methylamino)-N1-(4-cyanobenzyl)-L-alaninamide (1.3 g, 2.9 mmol; yield 96%).

Provenance & Evidence