Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5-[[4-[2-(Methylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione | HCID 10356320 | — |
| Reactant | HCID 17869012 | HCID 17869012 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 9908324 | HCID 9908324 | — |
Reaction Steps
A starting mixture consisting of 2.9 g (0.02 mol) 4-chloromethoxypyrimidine and 5.6 g (0.02 mol) 5-[4-(2-methylaminoethoxy)-benzyl]-thiazolidine-2,4-dione in 60 ml DMF and in the presence of 17 g NaHCO3 is heated at 100° C. for 24 h. Once the reaction completed, the mixture is poured onto 600 ml water and it is extracted with 4×200 ml AcOEt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07001910B1 |
|---|
| Source dataset | uspto-grants-2006_02 |
|---|
| ORD ID | ord-bdfe802ed36f49418ca088e5d7b26a09 |
|---|
| Source note | uspto-grants-2006_02 |
|---|
