(1-Methyl-3-piperidyl)methanol → 4-Amino-6-methoxy-7-(N-methylpiperidin-3-ylmethoxy)quinazoline

HRID 890968Notes

Reaction equation

HRID 890968 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([OH:14])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH3:15][N:16]1[CH2:21][CH2:20][CH2:19][CH:18]([CH2:22]O)[CH2:17]1>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH2:22][CH:18]3[CH2:19][CH2:20][CH2:21][N:16]([CH3:15])[CH2:17]3)=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 97998(1-Methyl-3-piperidyl)methanolHCID 135697903HCID 135697903, compound

Product 1

HCID 222437994-Amino-6-methoxy-7-(N-methylpiperidin-3-ylmethoxy)quinazoline

Procedure

4-Amino-6-methoxy-7-(N-methylpiperidin-3-ylmethoxy)quinazoline was prepared by reaction of 4-amino-6-methoxy-7-hydroxyquinazoline with 1-methyl-3-piperidinemethanol under analogous conditions to those described Example 2, Note[11]:—Mass Spectrum: M+H+ 303.

Sources & evidence

ORD record
ord-007000b536654d59b245d85df9a39976
Source dataset
uspto-grants-2006_02
Patent number
US07001904B1

Reaction notes

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