Trifluoroacetic acid → HCID 178486738, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 4, N-(tert-butoxycarbonylmethyl)-N′-(2,6-dimethylphenyl)-N″-[6-methoxy-7-(2-pyrrolidin-1-ylethoxy)quinazolin-4-yl]guanidine was reacted with trifluoroacetic acid to give the title compound in 65% yield; NMR Spectrum: (DMSOd6, 100° C.) 1.78 (m, 4H), 2.32 (s, 6H), 2.67 (m, 4H), 2.94 (t, 2H), 3.85 (s, 3H), 4.09 (s, 2H), 4.28 (t, 2H), 7.1 (s, 1H), 7.19 (s, 3H), 7.74 (s, 1H), 8.48 (s, 1H), 10.8–11.7 (br s, 1H); Mass Spectrum: M+H+ 493.

Provenance & Evidence