Trifluoroacetic acid → HCID 178486732, compound

Participants

Reaction Steps

A mixture of N-(2-tert-butoxycarbonylaminoethyl)-N′-(2,6-dimethylphenyl)-N″-[6-methoxy-7-(N-methylpiperidin-4-ylmethoxy)quinazolin-4-yl]guanidine (0.31 g), trifluoroacetic acid (1 ml) and methylene chloride (1 ml), was stirred at ambient temperature for 20 minutes. The reaction mixture was evaporated and the residue was dissolved in water (4 ml) and the solution was basified to pH10 by the addition of 10N aqueous potassium hydroxide solution. The mixture was extracted with a 19:1 mixture of methylene chloride and methanol. The organic extract was dried over magnesium sulphate and evaporated. There was thus obtained the title compound (0.16 g); NMR Spectrum: (DMSOd6) 1.2–1.4 (m, 2H), 1.65–1.94 (m, 5H),2.12 (s, 3H), 2.21 (s, 6H), 2.7–2.9 (m, 4H), 3.22 (br s, 3H), 3.4–3.8 (m, 4H), 3.91 (d, 2H), 7.0 (s, 1H), 7.13 (s, 3H), 8.4 (s, 1H); Mass Spectrum: M+H+ 492.

Provenance & Evidence