Diethylene Glycol Monomethyl Ether → HCID 22243778, compound

HRID 890976Notes

Reaction equation

HRID 890976 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1.[CH3:24][O:25][CH2:26][CH2:27][O:28][CH2:29][CH2:30]O>>[CH3:23][O:22][C:19]1[CH:20]=[CH:21][C:16]([CH2:15][NH:14][C:5]2[C:4]3[C:9](=[CH:10][C:11]([O:12][CH3:13])=[C:2]([O:1][CH2:30][CH2:29][O:28][CH2:27][CH2:26][O:25][CH3:24])[CH:3]=3)[N:8]=[CH:7][N:6]=2)=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 8134Diethylene Glycol Monomethyl EtherHCID 22243776HCID 22243776, compound

Product 1

HCID 22243778HCID 22243778, compound

Procedure

6-Hydroxy-4-(4-methoxybenzylamino)-7-methoxyquinazoline was reacted with 2-(2-methoxyethoxy)ethanol using an analogous procedure to that described in the second last paragraph of Note [1] immediately above that is concerned with the preparation of starting materials. There was thus obtained (4-(4-methoxybenzylamino)-7-methoxy-6-[2-(2-methoxyethoxy)ethoxy]quinazoline; NMR Spectrum: (CDCl3) 3.51 (m, 2H), 3.68 (m, 2H), 3.82 (s, 3H), 3.88 (m, 2H), 3.96 (s, 3H), 4.26 (m, 2H), 4.76 (d, 2H), 5.87 (t, 1H), 6.89 (d, 2H), 7.13 (s, 1H), 7.19 (s, 1H), 7.34 (d, 2H), 8.59 (s, 1H); Mass Spectrum: M+H+ 414.

Workup

  1. customthat is concerned with the preparation of starting materials

Sources & evidence

ORD record
ord-c4f0d35db7b24d25b060d5fab12ed228
Source dataset
uspto-grants-2006_02
Patent number
US07001904B1

Reaction notes

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