Methanol → HCID 178486727, compound

Participants

Reaction Steps

A mixture of N-(2-methoxycarbonylethyl)-N′-(2,6-dimethylphenyl)-N″-[6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl]guanidine (0.038 g), lithium hydroxide monohydrate (0.0063 g), THF (1 ml), methanol (0.5 ml) and water (0.5 ml) was stirred at ambient temperature for 16 hours. The mixture was evaporated and the residue was partitioned between water and methylene chloride. The aqueous layer was acidified by the addition of glacial acetic acid and evaporated. The resultant residue was extracted with methylene chloride. The organic extract was filtered and evaporated. There was thus obtained the title compound (0.034 g); NMR Spectrum: (CDCl3) 2.15 (m, 2H), 2.28 (s, 6H), 2.58 (s, 3H), 2.6–2.73 (m, 7H), 3.73 (t, 4H), 3.83 (s, 2H), 4.0 (s, 4H), 4.2 (t, 2H), 7.14 (s, 3H), 7.2 (s, 1H), 7.87 (s, 1H), 8.51 (s, 1H), 12.5 (s, 1H); Mass Spectrum: M+H+ 538.

Provenance & Evidence