Trifluoroacetic acid → HCID 178486725, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 4, N-[(S)-1-tert-butoxycarbonylethyl]-N′-(2,6-dimethylphenyl)-N″-[6-methoxy-7-(2-pyrrolidin-1ylethoxy)quinazolin-4-yl]guanidine was reacted with trifluoroacetic acid to give the title compound in 68% yield; NMR Spectrum: (DMSOd6, 100° C.) 1.47 (d, 3H), 1.75 (m, 4H), 2.33 (s, 6H), 2.67 (m, 4H), 2.93 (t, 2H), 3.88 (s, 3H), 4.28 (t, 2H), 4.58 (q, 1H), 7.13 (s, 1H), 7.19 (s, 3H), 7.75 (s, 1H), 8.48 (s, 1H),11.5 (br s, 1H); Mass Spectrum: M+H+ 505.

Provenance & Evidence