Trifluoroacetic acid → HCID 178486739, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 4, N-(tert-butoxycarbonylmethyl)-N′-(2,6-dimethylphenyl)-N″-[6-methoxy-7-(2-morpholinoethoxy)quinazolin-4-yl]guanidine was reacted with trifluoroacetic acid to give the title compound in 74% yield; NMR Spectrum: (DMSOd6, 100° C.) 2.17 (s, 6H), 3.27 (t, 4H), 3.5 (t, 2H), 3.6 (s, 3H), 3.8 (t, 4H), 4.48 (m, 4H), 7.15 (s, 1H), 7.2 (d, 2H), 7.26 (t, 2H), 8.7 (s, 1H); Mass Spectrum: M+H+ 509.

Provenance & Evidence