Hydrochloric Acid → 3-(4-Fluorophenyl)-5-isoxazolemethanol

Participants

Reaction Steps

[3-(4-fluorophenyl)isoxazol-5-yl]methyl acetate was stirred in a mixture of aqueous 2N sodium hydroxide (1.60 g, 20 mL H2O) and ethanol (10 mL) at room temperature for 2 hours. The reaction mixture was then neutralized with 2N HCl aqueous solution (20 mL), and extracted with ethyl acetate (2×30 mL). The combined organic layers were dried over sodium sulfate and solvent removed under reduced pressure, to provide [3-(4-fluorophenyl)isoxazol-5-yl]methan-1-ol. C. Conversion of a Compound of Formula (30) in which X1 is 4-Fluorophenyl to a Mesylate

Provenance & Evidence