Benzenesulfonyl isocyanate, 2-chloro- → 2-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl (2-chlorophenyl)sulfonylcarbamate
Reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][OH:22])=[CH:16][CH:15]=2)[N:3]=1.[Cl:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[S:30]([N:33]=[C:34]=[O:35])(=[O:32])=[O:31]>>[Cl:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[S:30]([NH:33][C:34](=[O:35])[O:22][CH2:21][CH2:20][C:17]1[CH:16]=[CH:15][C:14]([N:4]2[C:5]([CH3:13])=[C:6]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:2]([CH3:1])=[N:3]2)=[CH:19][CH:18]=1)(=[O:32])=[O:31]Participants
3
Procedure
The title compound was prepared according to the procedure described in step 2 of Example 1 from 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethanol (step 1 of Example 2) and 2-chlorobenzenesulfonyl isocyanate: 1H-NMR (CDCl3) δ 8.21 (1H, d, J=7.5 Hz), 7.55-7.20 (12H, m), 4.30 (2H, t, J=6.8 Hz), 2.91 (2H, t, J=6.8 Hz), 2.34 (3H, s), 2.28 (3H, s).
Sources & evidence
- ORD record
- ord-ffea8086f6dd4870a64645f953eccad6
- Source dataset
- uspto-grants-2006_02
- Patent number
- US07001917B2
Reaction notes
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