2,4-Dimethylthiazole-5-sulfonamide → HCID 22244535, compound

HRID 891104Notes

Reaction equation

HRID 891104 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=[O:31])OC3C=CC=CC=3)=[CH:16][CH:15]=2)[N:3]=1.[CH3:32][C:33]1[S:34][C:35]([S:39]([NH2:42])(=[O:41])=[O:40])=[C:36]([CH3:38])[N:37]=1>>[CH3:1][C:2]1[C:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23]([NH:42][S:39]([C:35]3[S:34][C:33]([CH3:32])=[N:37][C:36]=3[CH3:38])(=[O:40])=[O:41])=[O:31])=[CH:16][CH:15]=2)[N:3]=1

Participants

3

Reactant 2

HCID 128731882,4-Dimethylthiazole-5-sulfonamideHCID 22244550Phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate

Product 1

HCID 22244535HCID 22244535, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 22 from phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate (step 1 of Example 22) and 2,4-dimethyl-1,3-thiazole-5-sulfonamide: 1H-NMR [CDCl3/CD3OD(10:1)] δ 7.46-7.22 (9H, m), 6.20 (1H, br.s), 3.48-3.45 (2H, m), 2.88-2.82 (2H, m), 2.64 (3H, s), 2.59 (3H, s), 2.30 (3H, s), 2.20 (3H, s).

Sources & evidence

ORD record
ord-8650f9dff9894c4e9ec64cc5ee4b6cd3
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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