3-Chloro-4-fluorobenzenesulfonamide → HCID 22244576, compound

HRID 891114Notes

Reaction equation

HRID 891114 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=O)[O:24]C3C=CC=CC=3)=[CH:16][CH:15]=2)[N:3]=1.[Cl:32][C:33]1[CH:34]=[C:35]([S:40]([NH2:43])(=[O:42])=[O:41])[CH:36]=[CH:37][C:38]=1[F:39]>>[Cl:32][C:33]1[CH:34]=[C:35]([S:40]([NH:43][C:23]([NH:22][CH2:21][CH2:20][C:17]2[CH:16]=[CH:15][C:14]([N:4]3[C:5]([CH3:13])=[C:6]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=4)[C:2]([CH3:1])=[N:3]3)=[CH:19][CH:18]=2)=[O:24])(=[O:41])=[O:42])[CH:36]=[CH:37][C:38]=1[F:39]

Participants

3

Reactant 2

HCID 75098833-Chloro-4-fluorobenzenesulfonamideHCID 22244550Phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate

Product 1

HCID 22244576HCID 22244576, compound

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 42 from phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate (step 1 of Example 22) and 3-chloro-4-fluorobenzenesulfonamide: 1H-NMR (CDCl3) δ 8.03-8.01 (1H, m), 8.00-7.79 (1H, m), 7.46-7.21 (10H, m), 6.14 (1H, br.s), 3.49-3.42 (2H, m), 2.84 (2H, t, J=6.7 Hz), 2.31 (3H, s), 2.23 (3H, s).

Sources & evidence

ORD record
ord-df15ab2e55b94024a3cdfcbe114de363
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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