2,4-Difluorobenzenesulfonamide → 3-[1-(4-{2-[({[(2,4-Difluorophenyl)sulfonyl]amino}carbonyl)amino]ethyl}phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]benzamide

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 1 of Example 42 from phenyl 2-(4-{4-[3-(aminocarbonyl)phenyl]-3,5-dimethyl-1H-pyrazol-1-yl}phenyl)ethylcarbamate (step 6 of example 72) and 2,4-difluorobenzensulfonamide: MS (ESI) m/z 554 [M+H]+, 552 [M−H]−, 1H-NMR (CDCl3) δ 8.00-7.98 (1H, m), 7.83-7.73 (3H, m), 7.56-7.44 (2H, m), 7.22 (4H, s), 7.05-6.94 (1H, m), 6.20 (1H, br.s), 5.66 (1H, br.s), 3.47 (2H, t, J=6.2 Hz), 2.85 (2H, t, J=6.2 Hz), 2.21 (3H, s), 2.20 (3H, s).

Provenance & Evidence