2-Pyridinesulfonamide,5-chloro-(8CI,9CI) → HCID 22244686, compound

HRID 891136Notes

Reaction equation

HRID 891136 reaction equation
[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][NH:15][C:16](=O)[O:17]C3C=CC=CC=3)=[CH:9][CH:8]=2)[N:5]=[C:4]([C:25]([F:28])([F:27])[F:26])[C:3]=1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.[Cl:35][C:36]1[CH:37]=[CH:38][C:39]([S:42]([NH2:45])(=[O:44])=[O:43])=[N:40][CH:41]=1>>[Cl:35][C:36]1[CH:37]=[CH:38][C:39]([S:42]([NH:45][C:16]([NH:15][CH2:14][CH2:13][C:10]2[CH:11]=[CH:12][C:7]([N:6]3[C:2]([CH3:1])=[C:3]([C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=4)[C:4]([C:25]([F:26])([F:27])[F:28])=[N:5]3)=[CH:8][CH:9]=2)=[O:17])(=[O:43])=[O:44])=[N:40][CH:41]=1

Participants

3

Reactant 2

HCID 222445712-Pyridinesulfonamide,5-chloro-(8CI,9CI)HCID 22244671Phenyl 2-{4-[5-methyl-4-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}ethylcarbamate

Product 1

HCID 22244686HCID 22244686, compound

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 42 from phenyl 2-{4-[5-methyl-4-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}ethylcarbamate (step 7 of Example 52) and 5-chloro-2-pyridinesulfonamide: MS (ESI) m/z 564 [M+H]+, 562 [M−H]−, 1H-NMR (CDCl3) δ 78.54 (1H, s), 7.96-7.90 (2H, m), 7.47-7.19 (7H, m), 6.91-6.79 (2H, m), 6.65 (1H, br.s) 5.98 (1H, br.s), 3.44 (2H, t, J=6.6 Hz), 2.83 (2H, t, J=6.7 Hz), 2.20 (3H, s).

Sources & evidence

ORD record
ord-3eec3cc24b2c47da8d54ed1b95b6b8ca
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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