pyridine-3-sulfonamide → N-[({2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]pyridine-3-sulfonamide

HRID 891139Notes

Reaction equation

HRID 891139 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=[O:31])OC3C=CC=CC=3)=[CH:16][CH:15]=2)[N:3]=1.[N:32]1[CH:37]=[CH:36][CH:35]=[C:34]([S:38]([NH2:41])(=[O:40])=[O:39])[CH:33]=1>>[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:15]=[CH:16][C:17]([CH2:20][CH2:21][NH:22][C:23]([NH:41][S:38]([C:34]3[CH:33]=[N:32][CH:37]=[CH:36][CH:35]=3)(=[O:40])=[O:39])=[O:31])=[CH:18][CH:19]=2)[N:3]=1

Participants

3

Reactant 2

HCID 232710pyridine-3-sulfonamideHCID 22244550Phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate

Product 1

HCID 22244646N-[({2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]pyridine-3-sulfonamide

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 22 from phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate (step 1 of Example 22) and pyridine-3-sulfonamide: 1H-NMR [CDCl3/CD3OD(10:1)] δ 9.10 (1H, d, J=2.2 Hz), 8.71-8.70 (1H, m), 8.24 (1H, d, J=8.3 Hz), 7.45-7.16 (1H, m), 6.26 (1H, br.s), 3.42-3.33 (2H, m), 2.80-2.73 (2H, m), 2.29 (3H, s), 2.20 (3H, s).

Sources & evidence

ORD record
ord-4da7734103574047aa9b0f8eaad56c46
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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