3-Chloro-2,4-pentanedione → 2-[4-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)phenyl]ethanol

HRID 891146Notes

Reaction equation

HRID 891146 reaction equation
Cl.[NH:2]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][OH:12])=[CH:6][CH:5]=1)[NH2:3].[Cl:13][CH:14]([C:18](=O)[CH3:19])[C:15](=O)[CH3:16]>>[Cl:13][C:14]1[C:15]([CH3:16])=[N:3][N:2]([C:4]2[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][OH:12])=[CH:8][CH:9]=2)[C:18]=1[CH3:19]

Participants

3

Reactant 2

HCID 743283-Chloro-2,4-pentanedioneHCID 222447112-(4-Hydrazinophenyl)ethanol hydrochloride

Product 1

HCID 222445772-[4-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)phenyl]ethanol

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 1 from 2-(4-hydrazinophenyl)ethanol hydrochloride and 3-chloropentane-2,4-dione: MS (ESI) m/z 251 [M+H]+, 1H-NMR (CDCl3) δ 7.32-7.25 (4H, m), 3.76 (2H, t, J=6.7 Hz), 2.85 (2H, t, J=6.7 Hz), 2.32 (1H, br.s), 2.28 (3H, s), 2.27 (3H, s).

Sources & evidence

ORD record
ord-6c075a48d6474528af63e5402acfac2a
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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